GENETIC TESTING OF EMBRYOS

IVF / BIOPSY / PREIMPLANTATION GENETIC TESTING AND DIAGNOSIS

Pedieos IVF Center offers its patients the opportunity to genetically test their embryos created during an IVF treatment. These tests are provided in order to exclude embryos for transfer that may possibly carry genetic abnormalities such as monogenic defects, structural translocations or the wrong number of chromosomes.

 

The genetic testing of embryos can be achieved initially in our Center through a laboratory procedure known as “embryo biopsy”. This procedure involves the creation of zygotes through conventional IVF or ICSI techniques, the subsequent culture of these embryos to the fifth or sixth day of embryonic development ­­and the removal (biopsy) of few trophectoderm cells from apparently healthy embryos at the blastocyst stage. These sampled cells are sent out to the genetic laboratory where they perform all necessary tests. Biopsied embryos are cryopreserved through the vitrification method on the day of biopsy and stored in our freezing facility until we receive the genetic results. Patients receive counseling from the embryologist or their doctor informing them about the results and their options for further action. Embryos that have been found to be apparently genetically healthy are transferred upon request of the patient during a frozen embryo transfer cycle or FET (more information on FET can be found on our website here).

 

 

  • Pedieos IVF Center offers 4 different types of genetic testing of embryos:
  1. We are introducing a new preimplantation genetic testing for chromosomal aneuploidies (PGT-A) which can include more patients without any apparent medical indication. There are four categories:
  • For patients who wish to transfer only embryos which have been found to be genetically euploid (normal) and have the best chance of developing to a healthy pregnancy,
  • For those patients who have low ovarian reserves. It may now be possible to do multiple egg collections (multiple cycles) to collect more oocytes. This way we can biopsy and cryopreserve as many embryos as possible before attempting a pregnancy with the transfer of a genetically euploid (normal) embryo,
  • For patients who wish to avoid the invasive procedure of prenatal testing during their pregnancy, thus transferring only genetically healthy embryos in an IVF cycle,
  • For egg recipient patients, who wish to avoid the transfer of genetically untested embryos.
  1. For patients who have had repeated miscarriages, repeated implantation failures or given birth to a child with a genetic disorder and who are in the category of advanced maternal age (over 39 year old). This type of test also falls under the PGT-A type.
  2. For patients who are carriers of a certain genetic disorder, specifically a monogenic or single gene defect and do not wish to pass this to their offspring. Some examples of these defects are β-Thalassaemia and Cystic Fibrosis and fall under the type of PGT-M (preimplantation genetic testing for monogenic defects) test.
  3. For patients who are carriers of a structural rearrangement, such as reciprocal or Robertsonian translocations and wish to avoid transferring unbalanced chromosomes to their offspring. This test is named PGT-S (preimplantation genetic testing for structural rearrangements).

 

All genetic tests are performed by the collaborating genetic labs using state-of-the-art technologies, including Whole Genome Amplification (WGA) and Next Generation Sequencing (NGS).

  • Prices

Prices will be updated to reflect each type of genetic test. Upon consulting our Center, we can accommodate the need to pool biopsied embryos from different cycles (when the number of embryos developed is limited) and request to batch the genetic tests to minimize patients’ treatment costs and achieve better outcomes.

Please ask your doctor for more information or contact us directly to answer all your questions.